AustralieFrV1, Main, Exploration, bibRecord, 004091

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Identifieur interne : 004091 ( Main/Exploration ); précédent : 004090; suivant : 004092

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

Auteurs : KIAN FAN CHUNG [Royaume-Uni] ; Sally E. Wenzel [États-Unis] ; Jan L. Brozek [États-Unis] ; Andrew Bush [Royaume-Uni] ; Mario Castro [États-Unis] ; Peter J. Sterk [Pays-Bas] ; Ian M. Adcock [Royaume-Uni] ; Eric D. Bateman [Afrique du Sud] ; Elisabeth H. Bel [Pays-Bas] ; Eugene R. Bleecker [États-Unis] ; Louis-Philippe Boulet [Canada] ; Christopher Brightling [Royaume-Uni] ; Pascal Chanez [France] ; Sven-Erik Dahlen [Suède] ; Ratko Djukanovic [Royaume-Uni] ; Urs Frey [Suisse] ; Mina Gaga [Grèce] ; Peter Gibson [Australie] ; Qutayba Hamid [Canada] ; Nizar N. Jajour [États-Unis] ; Thais Mauad [Brésil] ; Ronald L. Sorkness [États-Unis] ; W. Gerald Teague [États-Unis]

Source :

The European respiratory journal [ 0903-1936 ] ; 2014.

RBID : Pascal:14-0057428

Descripteurs français

Pascal (Inist)
- Pathologie de l'appareil respiratoire, International, Monde, Recommandation, Définition, Evaluation, Traitement, Grave, Asthme, Forme grave.
Wicri :
- topic : Recommandation.

English descriptors

KwdEn :
- Asthma, Definition, Evaluation, International, Recommendation, Respiratory disease, Severe, Treatment, World.

Abstract

Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A Task Force, supported by the European Respiratory Society and American Thoracic Society, reviewed the definition and provided recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults. A literature review was performed, followed by discussion by an expert committee according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for development of specific clinical recommendations. When the diagnosis of asthma is confirmed and comorbidities addressed, severe asthma is defined as asthma that requires treatment with high dose inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming "uncontrolled" or that remains "uncontrolled" despite this therapy. Severe asthma is a heterogeneous condition consisting of phenotypes such as eosinophilic asthma. Specific recommendations on the use of sputum eosinophil count and exhaled nitric oxide to guide therapy, as well as treatment with anti-IgE antibody, methotrexate, macrolide antibiotics, antifungal agents and bronchial thermoplasty are provided. Coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy.

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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 Respiratory Dept and Asthma Centre, Athens Chest Hospital</s1>
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<author><name sortKey="Castro, Mario" sort="Castro, Mario" uniqKey="Castro M" first="Mario" last="Castro">Mario Castro</name>
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<s3>USA</s3>
<sZ>5 aut.</sZ>
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<author><name sortKey="Sterk, Peter J" sort="Sterk, Peter J" uniqKey="Sterk P" first="Peter J." last="Sterk">Peter J. Sterk</name>
<affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Dept of Respiratory Medicine, Academic Medical Centre</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
</inist:fA14>
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<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
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<author><name sortKey="Adcock, Ian M" sort="Adcock, Ian M" uniqKey="Adcock I" first="Ian M." last="Adcock">Ian M. Adcock</name>
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<author><name sortKey="Dahlen, Sven Erik" sort="Dahlen, Sven Erik" uniqKey="Dahlen S" first="Sven-Erik" last="Dahlen">Sven-Erik Dahlen</name>
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 Respiratory Dept and Asthma Centre, Athens Chest Hospital</s1>
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<country>Grèce</country>
<placeName><settlement type="city">Athènes</settlement>
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<country>Australie</country>
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<author><name sortKey="Hamid, Qutayba" sort="Hamid, Qutayba" uniqKey="Hamid Q" first="Qutayba" last="Hamid">Qutayba Hamid</name>
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<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
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<orgName type="university">Université McGill</orgName>
</affiliation>
</author>
<author><name sortKey="Jajour, Nizar N" sort="Jajour, Nizar N" uniqKey="Jajour N" first="Nizar N." last="Jajour">Nizar N. Jajour</name>
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<author><name sortKey="Teague, W Gerald" sort="Teague, W Gerald" uniqKey="Teague W" first="W. Gerald" last="Teague">W. Gerald Teague</name>
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<series><title level="j" type="main">The European respiratory journal</title>
<title level="j" type="abbreviated">Eur. respir. j.</title>
<idno type="ISSN">0903-1936</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
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</sourceDesc>
<seriesStmt><title level="j" type="main">The European respiratory journal</title>
<title level="j" type="abbreviated">Eur. respir. j.</title>
<idno type="ISSN">0903-1936</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Asthma</term>
<term>Definition</term>
<term>Evaluation</term>
<term>International</term>
<term>Recommendation</term>
<term>Respiratory disease</term>
<term>Severe</term>
<term>Treatment</term>
<term>World</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Pathologie de l'appareil respiratoire</term>
<term>International</term>
<term>Monde</term>
<term>Recommandation</term>
<term>Définition</term>
<term>Evaluation</term>
<term>Traitement</term>
<term>Grave</term>
<term>Asthme</term>
<term>Forme grave</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Recommandation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Severe or therapy-resistant asthma is increasingly recognised as a major unmet need. A Task Force, supported by the European Respiratory Society and American Thoracic Society, reviewed the definition and provided recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults. A literature review was performed, followed by discussion by an expert committee according to the GRADE (Grading of Recommendations, Assessment, Development and Evaluation) approach for development of specific clinical recommendations. When the diagnosis of asthma is confirmed and comorbidities addressed, severe asthma is defined as asthma that requires treatment with high dose inhaled corticosteroids plus a second controller and/or systemic corticosteroids to prevent it from becoming "uncontrolled" or that remains "uncontrolled" despite this therapy. Severe asthma is a heterogeneous condition consisting of phenotypes such as eosinophilic asthma. Specific recommendations on the use of sputum eosinophil count and exhaled nitric oxide to guide therapy, as well as treatment with anti-IgE antibody, methotrexate, macrolide antibiotics, antifungal agents and bronchial thermoplasty are provided. Coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy.</div>
</front>
</TEI>
<affiliations><list><country><li>Afrique du Sud</li>
<li>Australie</li>
<li>Brésil</li>
<li>Canada</li>
<li>France</li>
<li>Grèce</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>Suisse</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
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<li>Attique (région)</li>
<li>Grand Londres</li>
<li>Hollande-Septentrionale</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
<li>Provence-Alpes-Côte d'Azur</li>
<li>Québec</li>
<li>Svealand</li>
<li>État de São Paulo</li>
</region>
<settlement><li>Amsterdam</li>
<li>Athènes</li>
<li>Hamilton (Ontario)</li>
<li>Londres</li>
<li>Marseille</li>
<li>Montréal</li>
<li>Pittsburgh</li>
<li>Stockholm</li>
<li>São Paulo</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université McMaster</li>
<li>Université de Pittsburgh</li>
</orgName>
</list>
<tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Kian Fan Chung" sort="Kian Fan Chung" uniqKey="Kian Fan Chung" last="Kian Fan Chung">KIAN FAN CHUNG</name>
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<name sortKey="Adcock, Ian M" sort="Adcock, Ian M" uniqKey="Adcock I" first="Ian M." last="Adcock">Ian M. Adcock</name>
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<name sortKey="Djukanovic, Ratko" sort="Djukanovic, Ratko" uniqKey="Djukanovic R" first="Ratko" last="Djukanovic">Ratko Djukanovic</name>
<name sortKey="Kian Fan Chung" sort="Kian Fan Chung" uniqKey="Kian Fan Chung" last="Kian Fan Chung">KIAN FAN CHUNG</name>
</country>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Wenzel, Sally E" sort="Wenzel, Sally E" uniqKey="Wenzel S" first="Sally E." last="Wenzel">Sally E. Wenzel</name>
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<name sortKey="Jajour, Nizar N" sort="Jajour, Nizar N" uniqKey="Jajour N" first="Nizar N." last="Jajour">Nizar N. Jajour</name>
<name sortKey="Sorkness, Ronald L" sort="Sorkness, Ronald L" uniqKey="Sorkness R" first="Ronald L." last="Sorkness">Ronald L. Sorkness</name>
<name sortKey="Teague, W Gerald" sort="Teague, W Gerald" uniqKey="Teague W" first="W. Gerald" last="Teague">W. Gerald Teague</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Septentrionale"><name sortKey="Sterk, Peter J" sort="Sterk, Peter J" uniqKey="Sterk P" first="Peter J." last="Sterk">Peter J. Sterk</name>
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<name sortKey="Bel, Elisabeth H" sort="Bel, Elisabeth H" uniqKey="Bel E" first="Elisabeth H." last="Bel">Elisabeth H. Bel</name>
</country>
<country name="Afrique du Sud"><noRegion><name sortKey="Bateman, Eric D" sort="Bateman, Eric D" uniqKey="Bateman E" first="Eric D." last="Bateman">Eric D. Bateman</name>
</noRegion>
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<country name="Canada"><noRegion><name sortKey="Boulet, Louis Philippe" sort="Boulet, Louis Philippe" uniqKey="Boulet L" first="Louis-Philippe" last="Boulet">Louis-Philippe Boulet</name>
</noRegion>
<name sortKey="Hamid, Qutayba" sort="Hamid, Qutayba" uniqKey="Hamid Q" first="Qutayba" last="Hamid">Qutayba Hamid</name>
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International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

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